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dc.contributor.author Lee, Calvin Yin-Tat
dc.date.accessioned 2018-06-12T23:04:40Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10211.3/203773
dc.description.abstract Chemical contaminants in estuaries may interfere with an organism’s ability to ward against parasites and disease which can shape patterns of genetic diversity in populations, including at the Major Histocompatibility Complex (MHC) which helps recognize foreign pathogens. Here, we examine genetic variation in the MHC, in microsatellite repeats, and in mitochondrial control region (D-Loop) sequences to assess relationships between a tumor-causing pathogen known as X-cell disease, juvenile English sole (Parophrys vetulus), and contaminants in the San Francisco Estuary (SFE), CA. Functional molecular analysis was used to compare fish regionally and by infection status. Supertypes analysis showed no difference in supertype distributions regionally or by infection status, nor was there evidence of differentiation at microsatellite loci and Dloop. These results suggest contaminant distributions may be more fine-grained than patterns of English sole movement in SF Bay, possibly explaining the incidence of tumorous individuals throughout the bay. en_US
dc.format.extent iv, 58 leaves
dc.language.iso en en_US
dc.publisher San Francisco State University en_US
dc.rights Copyright by Calvin Yin Tat Lee, 2018
dc.source AS36 2018 BIOL .L44
dc.title Immunogenetic variation and tumor incidence of juvenile English sole (Parophrys vetulus) across an estuarine gradient of contaminants en_US
dc.type Thesis en_US
dc.description.embargoterms 6 months en_US
dc.date.embargountil 2018-12-09T23:04:40Z
dc.contributor.department Biology


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